Start of APELYM 3D project
Apelym 3D is a new joint project between IMACTIV-3D and INSERM U1048 aiming to analyze the restoration of lymphatic function and adipose tissue by 3D imaging in context of lymphedema. Imactiv-3D will work to implement innovative tools for 3D imaging specific of the lymphatic network in adipose tissue and facilitate the characterization of the effectiveness of therapeutic targets in preclinical models of lymphedema. Alongside Imactiv-3D, two teams of INSERM U1048 are involved Florence Tatin (Team 13), coordinator of the project who works on the molecular regulation of lymphangiogenic factors and Philippe Valet (Team 3) who will bring its expertise on adipokines and adipocytes metabolism. While lymphatic capillaries have been well explored in several tissues, less is known about the deeper collecting lymphatic vessels. Thanks to our complementary expertise, we will be able to explore this lymphatic network on adipose tissues to understand its involvement in lymphedema. Promising targets would be tested as potential actors of the lymphatic network regeneration. This collaborative project is supported by European Fund and Region Occitanie.